| Start of production 2006; End of production 2010  | Station wagon (estate) Power: from 190 Hp to 510 Hp
 Length 5165 mm (203.35 in.); Width 1922 mm (75.67 in.); Height 1674 mm (65.91 in.); Wheelbase 3215 mm (126.57 in.);
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| AMG R 63 V8 (510 Hp) 4MATIC 7G-TRONIC AMG SPEEDSHIFT 2006 - 2007 | Maximum speed: 250  km/h | 155.34 mph 0-100  km/h: 5.1  sec, 0-60 mph: 4.8 sec
 Fuel consumption: 16.3  l/100 km | 14 US mpg | 17 UK mpg | 6 km/l
 
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| R 500 V8 (388 Hp) 4MATIC G-TRONIC 2008 - 2010 | Maximum speed: 250  km/h | 155.34 mph 0-100  km/h: 6.3  sec, 0-60 mph: 6 sec
 Fuel consumption: 12.9-13.1  l/100 km | 18 - 18 US mpg | 22 - 22 UK mpg | 8 - 8 km/l
 
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| R 500 V8 (306 Hp) 4MATIC G-TRONIC 2006 - 2008 | Maximum speed: 245  km/h | 152.24 mph 0-100  km/h: 7  sec, 0-60 mph: 6.7 sec
 Fuel consumption: 13.3  l/100 km | 18 US mpg | 21 UK mpg | 8 km/l
 
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| R 350 V6 (272 Hp) G-TRONIC 2007 - 2010 | Maximum speed: 234  km/h | 145.4 mph 0-100  km/h: 8.2  sec, 0-60 mph: 7.8 sec
 Fuel consumption: 11.1-11.3  l/100 km | 21 - 21 US mpg | 25 - 25 UK mpg | 9 - 9 km/l
 
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| R 350 V6 (272 Hp) 4MATIC G-TRONIC 2006 - 2010 | Maximum speed: 230  km/h | 142.92 mph 0-100  km/h: 8.4  sec, 0-60 mph: 8 sec
 Fuel consumption: 11.7  l/100 km | 20 US mpg | 24 UK mpg | 9 km/l
 
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| R 350 CDI V6 (224 Hp) 4MATIC G-TRONIC 2009 - 2010 | Maximum speed: 222  km/h | 137.94 mph 0-100  km/h: 8.8  sec, 0-60 mph: 8.4 sec
 Fuel consumption: 9.3  l/100 km | 25 US mpg | 30 UK mpg | 11 km/l
 
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| R 320 CDI V6 (224 Hp) 4MATIC G-TRONIC 2007 - 2009 | Maximum speed: 222  km/h | 137.94 mph 0-100  km/h: 8.8  sec, 0-60 mph: 8.4 sec
 Fuel consumption: 9.3  l/100 km | 25 US mpg | 30 UK mpg | 11 km/l
 
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| R 320 BlueTec (210 Hp) G-TRONIC 2009 - 2010 | Maximum speed: 216  km/h | 134.22 mph 0-100  km/h: 8.9  sec, 0-60 mph: 8.5 sec
 Fuel consumption: 8.7  l/100 km | 27 US mpg | 32 UK mpg | 11 km/l
 
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| R 300 V6 (231 Hp) G-TRONIC 2009 - 2010 | Maximum speed: 222  km/h | 137.94 mph 0-100  km/h: 9.7  sec, 0-60 mph: 9.2 sec
 Fuel consumption: 11.1-11.3  l/100 km | 21 - 21 US mpg | 25 - 25 UK mpg | 9 - 9 km/l
 
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| R 300 CDI V6 (190 Hp) G-TRONIC 2009 - 2010 | Maximum speed: 210  km/h | 130.49 mph 0-100  km/h: 9.8  sec, 0-60 mph: 9.3 sec
 Fuel consumption: 9  l/100 km | 26 US mpg | 31 UK mpg | 11 km/l
 
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| R 280 V6 (231 Hp) G-TRONIC 2007 - 2009 | Maximum speed: 222  km/h | 137.94 mph 0-100  km/h: 9.7  sec, 0-60 mph: 9.2 sec
 Fuel consumption: 10.9  l/100 km | 22 US mpg | 26 UK mpg | 9 km/l
 
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| R 280 CDI V6 (190 Hp) G-TRONIC 2007 - 2009 | Maximum speed: 210  km/h | 130.49 mph 0-100  km/h: 9.8  sec, 0-60 mph: 9.3 sec
 Fuel consumption: 9  l/100 km | 26 US mpg | 31 UK mpg | 11 km/l
 
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